Clinical evaluation of the severity of acute pancreatitis in elderly patients

Background and study aims: Acute pancreatitis incidence in geriatric patients has increased in recent years. The aim of this study is to compare the clinical outcomes, laboratory findings of acute pancreatitis among patients aged 65-74 years, 75-84 years and ≥85 years.

Patients and methods: This retrospective study analyzed 500 patients aged 65 years and above, who were diagnosed with acute pancreatitis between 2012 and 2022. They were categorized into three groups based on their age: 65-74 years, 75-84 years, and ≥85 years. The primary outcome of the study focused on comparing the hospital mortality rates among the three age groups. The secondary outcomes involved comparing the length of hospital stay, intensive care unit admission, rates of endoscopic retrograde cholangiopancreatography (ERCP), and cholecystectomy requirement among the three age groups.

Results: The study’s primary outcome is the significantly higher mortality rate in the oldest age group (p=0.002). In addition, patients with a Bedside index score ≥3, severe pancreatitis according to the revised Atlanta criteria, necrotizing pancreatitis, and drug-induced pancreatitis had significantly higher mortality rates. Hospitalized patients in the intensive care unit also showed a statistically significant increase in mortality rates. Interestingly, the rate of cholecystectomy operations was significantly lower in the group with higher mortality (p=0.030). When evaluated in terms of secondary outcomes, no significant difference was found in all three age groups.

Conclusions: The findings of this study indicate that the oldest age group had a significantly higher mortality rate compared to the other age groups. As a result, early diagnosis and prompt treatment are of utmost importance to enhance outcomes in this vulnerable population.

Keywords: acute pancreatitis, oldest age, mortality.